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. Author manuscript; available in PMC: 2018 Dec 1.
Published in final edited form as: Mol Cancer Ther. 2017 Aug 11;16(12):2840–2848. doi: 10.1158/1535-7163.MCT-17-0400

Figure 3. Silencing of miR-720 induces apoptosis and G2/M cell cycle arrest in vitro and tumor growth suppression effects in vivo in an intratumoral xenograft mouse model.

Figure 3

A–B) Cell cycle analysis showing a significant decrease in S-phase along with a modest increase in the G2/M phase of 786-O and A498 cells after transfection with anti720. C–D) Apoptosis assay showing induction of apoptosis by anti720. Numbers on panels are mean populations±SEM. E) Tumor volume following intratumoral injection of control or anti720 into established tumors. Data represents the mean of each group (6 mice) and error bars are SD. Week 1 is the start of injection and tumor growth was followed for 6 weeks and each mice received a total of 11 injections. F) Representative pictures of mice injected with either control or miR-720 at the termination of experiment.