Figure 4. miR-720 gain of function exerts tumorigenic attributes in non-malignant cell line HK-2.
A) miR-720 expression after transient transfection of miR-720 mimic compared to pre-miR-negative control (cont-miR). B) miR-720 overexpression in non-malignant HK-2 cells induced cell proliferation. C–F) An increase in the migration (C–D) and invasion (E–F) of HK-2 cells. G) A significant decrease in the expression of E-cadherin and αE-catenin in HK-2 cells overexpressing miR-720 compared to control.