Fig. 3.

Immunological findings during the first year of HIV-1-like SIVagm infection. a Increase of urinary neopterin levels at the indicated days post-infection (dpi) relative to the values measured prior to SIV infection. b, c Levels of CD16+ NK (b) and CCR5+ or CXCR3+/CCR5+ CD4+ (left) and CD8+ (right) T cells (c) at the indicated weeks post-infection (wpi) relative to the baseline values (100%). The shaded area indicates time points prior to infection. d Percentages of activated HLA-DR+ CD4+ and CD8+ T cells in duodenum prior to infection and at six wpi. Shown are mean values obtained for the three animals per group (+SEM). e Percentages of CCR5+ CD4+ T cells and activated HLA-DR+ CD4+ and CD8+ T cells in bronchoalveolar lavage obtained at 55, 64, and 72 wpi. p-values were calculated using the two-tailed unpaired Student's-t-test and significant differences are indicated as: *p < 0.05; **p < 0.01; ***p < 0.001