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. 2018 Apr 10;8:5734. doi: 10.1038/s41598-018-24076-w

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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TBT decreased cell viability and induced apoptosis in β-cells. RIN-m5F cells were treated with or without TBT (0.1–1 μM) for 1–24 h. (A) Cell viability was determined by MTT assay in a dose-dependent manner (a) and a time-dependent manner (b). (B) Apoptotic or necrotic cells were determined by flow cytometry analysis with acridine orange/ethidium bromide fluorescent probes. Data are presented as mean ± SEM of four independent experiments with triplicate determinations in each experiment. *P < 0.05 as compared to vehicle control.