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. 2018 Apr 10;8:5745. doi: 10.1038/s41598-018-23965-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Metformin in utero does not alter weight gain, glucose or insulin levels in males. Male offspring of dams exposed to metformin (•) as compared to control offspring (). Weight gain was tracked weekly (a) (n = 16–20). Fasted insulin and glucose levels (b and c) were collected every 4–6 weeks (n = 6–13). Random glucose and insulin levels were collected at birth and then every 4–6 weeks (d and e) (n = 6–13).

Inline graphic — Metformin in utero does not alter weight gain, glucose or insulin levels in males. Male offspring of dams exposed to metformin (•) as compared to control offspring (). Weight gain was tracked weekly (a) (n = 16–20). Fasted insulin and glucose levels (b and c) were collected every 4–6 weeks (n = 6–13). Random glucose and insulin levels were collected at birth and then every 4–6 weeks (d and e) (n = 6–13).