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. 2018 Apr 10;8:5745. doi: 10.1038/s41598-018-23965-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Increased islet calcium entry in male offspring from metformin exposed dams. Calcium entry as measured by FURA-2 imaging. A representative tracing of control (■) versus metformin (▲) islets in response to high glucose with a quantification of the calcium response (a). Representative tracings and calcium quantification for responses to 30 mM potassium chloride (b) for control (●) versus metformin (■) islets. These tracings represent n = 6 animals per group run on 3 separate experiments. (c) Expression of calcium channel subunits from islets isolated from 4–5 month old animals, n = 9 ***p < 0.001, *p < 0.05.