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. 2018 Apr 10;9:1368. doi: 10.1038/s41467-018-03777-w

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — ¹³C–MeOH protocol to quantify serine catabolism to formate in vivo. a Diagram tracing the metabolism of ¹³C methanol and its intersection with serine catabolism to formate. b–i time-dependent Mass Isotopomer Distribution (MID) of different metabolites in different tissues after a 3 g/kg IP injection of ¹³C–MeOH. b, c Plasma formate and serine MID. d–f Serine MID in liver, spleen and brain. g–i Purine MID in liver, spleen and brain. j–l P1C MID in total purines in liver, spleen and brain. Results were obtained from four mice per time point (n = 4). Error bars denote s.e.m