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. 2018 Apr 4;9:677. doi: 10.3389/fimmu.2018.00677

Figure 6.

Figure 6

Transmission electron microscope histology of the lung in mice infected with recombinant Mycobacterium smegmatis. (A–D) Type II pneumocyte. (E,F) Small vein. (A,E) PBS. (B,F) pMVp262/MS. Rv0888NS/MS-treated mice (n = 3 per group) show that the number of mitochondrial cristae decreased, ruptured, and degenerated (C), blue arrow and mitochondrial autophagy (C), green arrow, ruptured membrane of the lamellar body (D), red arrow; platelet-rich microthrombi (G), cyan arrow; small blood vessels edema (H), purplish-red arrow. Images are representative of one of three independent experiments with three lung sections per group. Abbreviations: RBC: red blood cells; LB: lamellar body; MIT: mitochondrial; Mφ: macrophage; ep-II NC: type II pneumocyte nuclear chromatin; CYT: cytoplasm; CAP: capillary; MONO: monocytes. Scale bars: (A–D) 0.5 µm; (E,F), 5 µm.