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. 2018 Apr 4;9:318. doi: 10.3389/fphys.2018.00318

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Copyright © 2018 Moraes, Silva, Thompson, Santos, Santos, Fernandes, Morales, Martins, Capelozzi, de Abreu, Pelosi and Rocco.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Expression of biomarkers associated with extracellular matrix damage and metalloproteinase. Real-time polymerase chain reaction analysis of markers of extracellular matrix damage (syndecan-1 and decorin) and of metalloproteinase (MMP)-9. Relative gene expression was calculated as the ratio of average gene expression levels to reference gene (36B4) expression and presented as fold change relative to non-ventilated animals (NV). Values are medians and interquartile ranges of 7 rats in each group. Comparisons among all groups were done by the Kruskal-Wallis test followed by Dunn's test (p < 0.05). *vs. V_T = 6 mL/kg (p < 0.05). ^#vs. V_T = 13 mL/kg (p < 0.05).