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GA attenuated the capacity of AP-1 binding to DNA in biomechanically stimulated HUVECs. HUVECs were treated with GA (40 μM) or DMSO control vehicle for 1.5 h and subjected to biomechanical stretch (15% cyclic elongation at 0.5 Hz) for 6 h. Binding of the mechanosensitive transcription factor AP-1 was assessed in an EMSA assay (***p < 0.001 vs. DMSO, ###p < 0.001 vs. DMSO stretch, n = 3). Signal intensity (gray value) of DMSO-treated cells was set to 100%.
