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Arterial O2 saturation recorded in adult rats and mice living at sea level (SL—Quebec-city, Canada), and at high altitude (HA—La Paz, Bolivia, 3,600 m) during exposure to 160 or 90 mmHg. All values are mean + s.e.m. Number of animals in each group at SL: n = 10 mice, 6 rats. Number of animals in each group at HA: n = 9 mice, 6 rats. **P < 0.01, ***P < 0.001, and **** P < 0.0001 HA vs. SL. ◦P < 0.05, and ◦◦◦◦P < 0.0001 mice vs. rats.
