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. 2018 Apr 4;9:311. doi: 10.3389/fphys.2018.00311

Figure 6.

Figure 6

Upper panels: Activity of NADPH oxidase (NOX), xanthine oxidase (XO), copper-zinc superoxide dismutase (SODCu−Zn), and glutathione peroxidase (GPx) measured in cytosolic (Cyto) lung extracts. Lower panels: Activity of manganese superoxide dismutase (SODMn), glutathione peroxidase (GPx), and cytochrome-c oxidase (COX) measured in mitochondrial (Mito) lung extracts in young (postnatal day 15) rats living at sea level (SL—Quebec-city, Canada), and at high altitude (HA—La Paz, Bolivia, 3,600 m), following exposure to ambient O2 level (control), hypoxia (at SL−13.5% O2), or O2 enrichment (at HA−32% O2) between postnatal days 4–14. All values are mean + s.e.m. Values for NOX, XO, GPx, and SOD are in nmol/min/μg protein, and for COX in pmol O2/sec/mg protein (see text for further details). Number of animals in each group at SL: control and hypoxic rats n = 9 and 8, and at HA: control and O2 enrichment rats n = 8 and 6. *P < 0.05 ± O2 vs. Cont. ◦P < 0.05, and ◦◦P < 0.01 HA vs. SL.