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. 2018 Apr 4;12:14. doi: 10.3389/fninf.2018.00014

Figure 11.

Figure 11

Simulating stochastic synaptic release via NeuroMatic's Pulse tab. Screen capture of NeuroMatic's Pulse tab after clicking the Model button, selecting “Granule Cell Multinomial Synapse” and entering the following parameters via NeuroMatic's prompts: N = 5, Qp = −20 pA, P = 0.5, CVQS = 0.3, σQL = 0.08 ms, CVQII = 0.3, no spillover. The time course of quantal release at each site was automatically set to the NeuroMatic function NMSynExp (Equation 1) with values: τr = 0.116 ms, n = 1, ad1 = 86.72, τd1 = 0.36 ms, ad2 = 13.28, τd2 = 2.034 ms. Final configurations for each release site were listed on the Pulse tab, as shown here, including each site's P (binomial = 0.5). After clicking the Execute button, NeuroMatic generated 150 output waves with prefix name “EPSC.” The waves were automatically selected for visualization and analysis (see Figure 12).