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. 2018 Apr 4;9:278. doi: 10.3389/fphar.2018.00278

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Copyright © 2018 Liu, He, Wang, Xin, Wang, Li and Fu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The recruitment of TLR4 to lipid rafts was inhibited by taraxasterol. Fractions 3–4 correspond to lipid rafts. Representative blots of three separate experiments are shown. TLR4 content of macrophage lipid rafts was calculated as a percentage of total membrane TLR4 (lipid rafts + non-rafts). The values presented are the means ± SEM of three independent experiments. ^#p < 0.05 vs. control group; ^∗p < 0.05, ^∗∗p < 0.01 vs. LPS group.