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. 2018 Apr 4;9:621. doi: 10.3389/fimmu.2018.00621

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Copyright © 2018 Saito, Suzuki, Yoshimoto, Kaneko, Yamaoka, Shimizu, Mori, Okamoto, Kameyama, Amano, Tamaru, Tokuhira and Takeuchi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Classification of LPD patients and patient flow. Twenty-two and 13 patients were divided into the regressive and persistent groups, respectively, according to LPD regression assessment at week 12. Control patients were age-, sex-, rheumatoid arthritis duration-, and MTX dose-matched with LPD patients (N = 35). Flow cytometric analysis of whole blood sample and cytokine analysis of serum sample were conducted for 10 patients from the control group, 7 patients from the regressive group, and 3 patients from the persistent group. MTX, methotrexate; LPD, lymphoproliferative disorder.