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. 2018 Apr 4;9:621. doi: 10.3389/fimmu.2018.00621

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Copyright © 2018 Saito, Suzuki, Yoshimoto, Kaneko, Yamaoka, Shimizu, Mori, Okamoto, Kameyama, Amano, Tamaru, Tokuhira and Takeuchi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Changes in serum cytokines after methotrexate (MTX) cessation in lymphoproliferative disorder (LPD) patients. Transition of (A) interferon (IFN)-γ, (B) IL-2, (C) IL-12p70, (D) IL-7, (E) IL-15, (F) IL-10, and (G) TNF-α after MTX cessation. Comparison between the three groups was conducted using the Kruskal–Wallis test. ^†Regressive vs. control, P < 0.05. ^‡Regressive vs. control, P < 0.05; regressive vs. persistent, P < 0.05. *P < 0.05 for comparison with the value at week 0 in each group.