Table 3.
Proportion and absolute numbers of lymphocyte subsets.
| Regressive group (n = 7) | Persistent group (n = 3) | Control group (n = 10) | Regressive vs. persistent, P | Regressive vs. control, P | Persistent vs. control, P | |
|---|---|---|---|---|---|---|
| Proportion (%) | ||||||
| CD3+ T cells/lymph | 68.1 (49.2–78.9) | 78.2 (63.6–83.7) | 62.2 (50.7–72.2) | 0.59 | 0.36 | 0.08 |
| CD4+/CD3+T cells | 63.0 (44.6–82.2) | 70.8 (56.0–77.6) | 71.8 (55.3–80.8) | 1.00 | 0.73 | 0.93 |
| Naïve/CD4+ T | 26.6 (24.0–45.7) | 31.4 (28.5–36.2) | 34.5 (19.1–38.2) | 0.65 | 0.96 | 1.00 |
| Central memory/CD4+ T | 41.6 (29.3–46.1) | 36.6 (33.9–44.0) | 43.1 (37.4–49.1) | 0.66 | 0.31 | 0.27 |
| Effector/CD4+ T | 1.1 (0.3–4.3) | 0.4 (0.3–0.6) | 1.4 (0.3–2.6) | 0.27 | 0.81 | 0.49 |
| Effector memory/CD4+ T | 14.2 (6.1–31.6) | 18.0 (13.7–25.6) | 16.2 (11.9–20.9) | 0.65 | 0.81 | 0.67 |
| Th1/CD4+ T | 14.8 (6.7–17.3) | 19.8 (12.4–21.1) | 18.1 (17.0–28.9) | 0.17 | 0.02* | 0.58 |
| Th2/CD4+ T | 65.2 (60.2–72.5) | 55.8 (37.5–63.9) | 64.0 (52.4–68.7) | 0.17 | 0.46 | 0.36 |
| Th17/CD4+ T | 16.2 (11.7–18.8) | 12.9 (8.0–15.8) | 11.7 (7.6–13.5) | 0.26 | 0.05 | 0.71 |
| Th1/Th17/CD4+ T | 4.1 (2.6–8.0) | 8.4 (7.3–37.2) | 6.2 (4.3–11.6) | 0.07 | 0.34 | 0.14 |
| Treg/CD4+ T | 9.7 (3.6–11.5) | 6.5 (5.8–7.5) | 7.4 (5.6–9.2) | 0.17 | 0.09 | 0.45 |
| CD8+/CD3+ T cells | 28.4 (14.0–49.2) | 16.2 (12.9–25.3) | 23.3 (14.9–30.7) | 0.45 | 0.66 | 0.36 |
| Naïve/CD8+ T | 26.1 (14.9–40.4) | 12.2 (5.1–31.2) | 11.2 (9.3–16.5) | 0.80 | 0.01* | 0.26 |
| Central memory/CD8+ T | 18.3 (10.9–23.9) | 16.7 (9.2–20.4) | 10.9 (3.6–18.5) | 0.82 | 0.05 | 0.27 |
| Effector/CD8+ T | 19.8 (6.7–30.4) | 15.0 (8.2–30.6) | 19.1 (11.8–27.5) | 1.00 | 0.73 | 0.67 |
| Effector memory/CD8+ T | 22.5 (15.7–25.4) | 34.3 (26.6–40.9) | 45.7 (37.0–49.1) | 0.02* | <0.01* | 0.08 |
| EBV–specific CD8+/CD8+ T | 0.1 (0.1–0.2) | 0.4 (0.3–0.6) | 0.6 (0.4–1.2) | 0.11 | 0.02* | 0.56 |
| B cells/lymph | 8.8 (1.6–12.1) | 3.3 (3.0–17.3) | 11.9 (6.8–15.2) | 1.00 | 0.19 | 0.55 |
| NK cells/lymph | 9.6 (5.8–33.1) | 7.1 (5.8–9.55) | 16.0 (12.5–23.4) | 0.49 | 0.59 | 0.06 |
| Absolute numbersa | ||||||
| Lymphocytes | 480 (248–648) | 2,001 (1872–2070) | 1,522 (1,077–1,941) | 0.02* | <0.01* | 0.15 |
| CD3+ T cells | 288 (153–534) | 1,565 (1,317–1,567) | 837 (680–1,037) | 0.02* | 0.01* | 0.05 |
| CD4+ T cells | 257 (54–439) | 1,021 (876–1,109) | 639 (447–693) | 0.01* | <0.01* | 0.02* |
| Naïve CD4+ T | 82 (11–185) | 318 (316–321) | 185 (121–235) | 0.02* | 0.05 | 0.05 |
| Central memory CD4+ T | 107 (24–148) | 375 (320–449) | 271 (237–313) | 0.04* | <0.01* | 0.02* |
| Effector CD4+ T | 2 (1–19) | 4 (3–6) | 8 (2–16) | 0.82 | 0.31 | 0.45 |
| Effector memory CD4+ T | 20 (15–45) | 157 (140–284) | 92 (61–195) | 0.02* | <0.01* | 0.08 |
| Th1 | 26 (8–47) | 206 (168–209) | 114 (82–220) | 0.02* | <0.01* | 0.27 |
| Th2 | 189 (38–320) | 552 (510–666) | 374 (269–487) | 0.02* | 0.01* | 0.06 |
| Th17 | 36 (7–84) | 156 (83–174) | 60 (50–85) | 0.07 | 0.20 | 0.05 |
| Th1/17 | 9 (2–26) | 88 (73–506) | 34 (23–79) | 0.02* | 0.02* | 0.10 |
| Tregs | 16 (6–37) | 78 (64–79) | 36 (25–52) | 0.02* | 0.04* | 0.02* |
| CD8+ T cells | 75 (51–97) | 212 (201–395) | 192 (118–281) | 0.07 | 0.02 | 0.55 |
| Naïve CD8+ T | 19 (9–83) | 25 (20–66) | 20 (16–32) | 0.36 | 0.46 | 0.27 |
| Central memory CD8+ T | 11 (9–28) | 36 (24–43) | 20 (10–26) | 0.17 | 0.66 | 0.08 |
| Effector CD8+ | 20 (4–22) | 30 (17–122) | 27 (18–79) | 0.17 | 0.05 | 1.00 |
| Effector memory CD8+ T | 16 (8–28) | 69 (49–162) | 82 (49–132) | 0.02* | <0.01* | 0.93 |
| EBV-specific CD8+ T | 0 (0–1) | 2 (1–3) | 2 (1–7) | 0.11 | 0.02* | 0.85 |
| B cells | 43 (4–110) | 62 (60–358) | 143 (98–454) | 0.37 | 0.01* | 0.55 |
| NK cells | 64 (60–99) | 142 (109–198) | 272 (147–394) | 0.07 | 0.01* | 0.27 |
Th, T helper; EBV, Epstein–Barr virus; NK, natural killer.
aNumber per 1 mm3 whole blood are indicated as absolute numbers.
Values indicate median (Q1–Q3).
*P < 0.05.