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. 2018 Apr 4;6:35. doi: 10.3389/fbioe.2018.00035

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Copyright © 2018 Zlabinger, Lukovic, Hemetsberger, Gugerell, Winkler, Mandic, Traxler, Spannbauer, Wolbank, Zanoni, Kaun, Posa, Gyenes, Petrasi, Petnehazy, Repa, Hofer-Warbinek, de Martin, Gruber, Charwat, Huber, Pavo, Pavo, Nyolczas, Kraitchman and Gyöngyösi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Expression of homing and angiogenic signals of the myocardium 7 days after cardiac transfer of green fluorescent protein (GFP)-Luc-mesenchymal stem cell (MSCs). Fluorescent immunohistochemistry of the bioluminescence positive myocardial areas 7 days after intramyocardial [left panel (A,C,E,G)] or intracoronary [right panel (B,D,F,H)] GFP-Luc-MSCs delivery shows increased expression of homing signals cadherin (A,B), and angiogenic factors fibroblast growth factor 2 (FGF2) (C,D) and vascular endothelial growth factor (VEGF) (E,F) in group IM. Infarct area border zone (G,H) exhibited higher number of myocardial cells and higher level of VEGF expression in group IM (G). Hoechst staining of the nuclei, 40× magnification. Expression of homing signals cadherin (I), stromal-derived factor-1alpha (J), and angiogenic factors FGF2 (K) and VEGF (L).