Table 3.
General features and vascular risk factors according to clinical outcome at discharge modified Rankin scale (mRs) in patients with cerebral venous thrombosis.
| Good clinical outcome (mRs 0–2)n = 240 (%) | Bad clinical outcome (mRs 3–6) n = 103 (%) | Total N = 343 (%) | p | |
|---|---|---|---|---|
| Age, yearsa | 28 (22–37) | 29 (23–40) | 29 (22–38) | 0.32 |
| Risk factors | ||||
| Oral contraceptive | 9 (8.7) | 40 (16.7) | 48 (14.1) | 0.004 |
| Pregnancy related | 28 (11.8) | 19 (18.4) | 47 (13.9) | 0.10 |
| Puerperium | 92 (38.5) | 42 (40.8) | 134 (39.2) | 0.70 |
| Current smoking | 16 (15.5) | 20 (8.3) | 36 (10.5) | 0.04 |
| Previous VPT | 15 (6.3) | 4 (3.9) | 19 (5.5) | 0.38 |
| Known acquired thrombophilia | 7 (2.9) | 2 (1.3) | 9 (3.0) | 0.27 |
| Therapeutic approach (discharge) | 0.35 | |||
| Anticoagulation | 159 (66.3) | 85 (82.5) | 244 (71.1) | 0.002 |
| Antiplatelet | 81 (33.8) | 18 (17.5) | 99 (28.9) | 0.002 |
| Etiology | ||||
| Provoked CVTb | 145 (60.4) | 64 (62.1) | 209 (60.9) | 0.76 |
| Prothrombotic conditionsc | 48 (20.0) | 20 (19.4) | 68 (19.8) | 0.90 |
| Unknown | 33 (13.7) | 33 (32.0) | 66 (19.2) | 0.001 |
aMedian (interquartile range).
*p-Value by U-Mann–Whitney Wilcoxon.
bProvoked CVT: pregnancy and puerperium, oral contraceptives, drugs, parameningeal infections, systemic diseases, cancer related.
cProthrombotic conditions: antithrombin III deficiency, protein C deficiency, protein S deficiency, anti-phospholipid syndrome, mutation G20210A of factor II, hyperhomocysteinemia.
VPT, venous peripheral thrombosis; CVT, cerebral venous thrombosis; mRs, modified Rankin score.