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. 2018 Apr 4;9:640. doi: 10.3389/fimmu.2018.00640

Figure 1.

Figure 1

Expression profile of microRNAs is altered during cutaneous leishmaniasis caused by L. braziliensis. MicroRNA probes that were differentially expressed (p < 0.05 and −1.5< fold change >1.5) between healthy control (HC; orange bar) and localized cutaneous leishmaniasis (LCL; brown bar) skin samples were included in this analysis. Heat maps showing the expression profile of (A) 33 microRNA probes from GSE55664 and (B) 44 microRNA probes from GSE63931. Rows represent microRNA probes and columns represent samples. Unsupervised hierarchical clustering of the samples was performed using the Euclidean distance method; Principal Component Analysis using microRNA probes that were differentially expressed between the HC and LCL skin samples were conducted for (C) GSE55664 or (D) GSE63931 data sets. Each symbol represents one sample; fold changes of microRNA probes modulated in LCL relative to HC samples are shown for (E) GSE55664 and (F) GSE63931 data sets.