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. 2018 Apr 4;9:640. doi: 10.3389/fimmu.2018.00640

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Copyright © 2018 Nunes, Silva, Ampuero, Noronha, Souza, Correia, Khouri, Boaventura, Barral, Ramos, Brodskyn, Oliveira and Tavares.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The expression of miR-193b and -671 and their target genes as key in localized cutaneous leishmaniasis (LCL) outcome. (A) Representative image of molecules from innate immune response pathways and their respective microRNAs with opposite expression (↑miR ↓target or ↓miR ↑target). (B) Correlation matrix between the expression of microRNAs and their target genes. Circles and corresponding sizes represent significance (p < 0.05) and r-values for each Spearman correlation, respectively. Colors represent the directionality of the correlation (blue infers positive correlation, whereas red indicates negative correlations). (C) p-Values of negative Spearman correlations between miR-193b and the indicated target genes are shown. (D) p-Values of positive Spearman correlations between miR-671 and the indicated target genes are described. Spearman correlations between (E) miR-193b/CD40 and (F) miR-671/TNFR. (G) Network analysis shows Spearman correlations (−0.6 < r > 0.6) between microRNAs and target genes according to the response to treatment (cured by 59, 60–89 or >90 days). Colors represent the directionality of the correlation (red line, negative correlation and blue line, positive correlation; red circles, upregulated and green circles, downregulated genes).