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. 2018 Apr 4;9:612. doi: 10.3389/fimmu.2018.00612

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Copyright © 2018 Michels, van de Kar, Okrój, Blom, van Kraaij, Volokhina and van den Heuvel.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Convertase activity profiles of patients with C3 glomerulopathy over disease course. Patient serum samples of P24 (A), P27 (B), P25 (C), and P26 (D) from different collection dates associated with different disease states were tested mixed 1:1 with pooled normal human serum (NHS) to a final concentration of 3.75% in experiments shown in panels (C,D) or 5% in the experiments shown in panels (A,B), since they were performed using different batches of erythrocytes. Abbreviations: Acu, acute phase at first clinical presentation of disease; Act, active disease; Part Rem, partial remission; Rem, remission. Heat-inactivated NHS (ΔNHS) and an NHS sample from which guinea pig serum were omitted during the second part of the assay (no step 2) served as negative controls for the first and second steps, respectively. Representative data are given. Hemolysis levels are given as percentage of full lysis of erythrocytes in water.