Table 3.

Estimated change in global and domain-specific cognitive functioning 1-year after randomization in control (n = 641) and intervention (n = 638) groups.

Global cognition	β-Coefficient (95% confidence interval)a		p-valueb
	Control	Intervention
CTS
Baseline	1.98 (1.07; 2.90)	−0.12 (−0.22; −0.02)	0.020
Group × time	0.24 (0.18; 0.30)	0.04 (−0.04; 0.13)	0.321
Cognitive domains
Perceptual speed
Baseline	2.73 (2.02; 3.44)	0.04 (−0.3; 0.12)	0.263
Group × time	0.08 (0.04; 0.13)	−0.03 (−0.09; 0.03)	0.314
Executive functions
Baseline	1.12 (0.43; 1.80)	−0.11 (−0.19; −0.03)	0.010
Group × time	0.14 (0.08; 0.21)	0.02 (−0.07; 0.11)	0.698
Episodic memory
Baseline	1.13 (0.39; 1.86)	−0.08 (−0.16; −0.003)	0.042
Group × time	0.17 (0.12; 0.21)	0.004 (−0.06; 0.07)	0.890
Verbal abilities
Baseline	2.27 (1.35; 3.20)	0.02 (−0.09; 0.12)	0.773
Group × time	0.17 (0.10; 0.24)	−0.07 (−0.17; 0.02)	0.109
Constructional praxis
Baseline	0.10 (−0.74; 0.94)	0.02 (−0.08; 0.12)	0.688
Group × time	−0.08 (−0.17; −0.001)	−0.05 (−0.16; 0.06)	0.396

CTS, CERAD total score; MMSE, Mini-Mental State Examination.

^aMixed-effect models were adjusted for baseline age, sex, education, center, and interviewer.

^bp-value < 0.05.