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. 2018 Apr 4;9:147. doi: 10.3389/fphys.2018.00147

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Copyright © 2018 Porter, van Duijvenboden, Bishop, Orini, Claridge, Gould, Sieniewicz, Sidhu, Razavi, Rinaldi, Gill and Taggart.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Cardiac resynchronization therapy defibrillator (CRT-D) device programmed to pace from the right ventricular (RV) electrode and record a local unipolar electrogram (UEG) from the left ventricular (LV) electrode. (B) Relationship between the unipolar electrogram and the intracellular ventricular transmembrane potential showing correspondence between activation recovery interval (ARI) and action potential duration (APD). (C) Example UEG recorded from the left ventricular lead and the computed ARI values for the same electrogram trace.