Table 3.
Effect of SCE on fasting blood glucose and glucose tolerance in diabetic rats ( ± SD, n = 8).
| Groups | Dose (mg/kg/day) | Blood glucose (mmol/L) |
AUC (mmol/L⋅h) | |||
|---|---|---|---|---|---|---|
| FBG | 0.5 h | 1 h | 2 h | |||
| Control | – | 5.19 ± 0.27 | 7.54 ± 0.53 | 8.44 ± 0.65 | 5.99 ± 0.44 | 13.33 ± 0.72 |
| DM | – | 20.20 ± 3.28** | 30.40 ± 3.68** | 29.85 ± 5.74** | 29.10 ± 2.06** | 57.28 ± 4.30** |
| MET | 162 | 10.89 ± 2.35## | 21.37 ± 5.65## | 20.31 ± 5.65## | 16.00 ± 8.07## | 36.09 ± 11.12## |
| SCE-L | 54 | 16.89 ± 2.77 | 29.99 ± 2.79 | 31.85 ± 1.33 | 28.14 ± 4.15 | 55.31 ± 4.48 |
| SCE-M | 108 | 11.14 ± 6.64## | 23.48 ± 5.78## | 29.93 ± 4.18 | 23.06 ± 5.08# | 43.56 ± 9.80## |
| SCE-H | 324 | 16.23 ± 2.91 | 29.49 ± 2.35 | 32.33 ± 1.27 | 26.70 ± 2.06 | 53.57 ± 3.09 |
Control: rats were fed with normal diet. DM: diabetes mellitus, rats were fed with high-energy diet and treated with STZ. MET (metformin): DM + MET. SCE (Semen Cassiae extract): DM + SCE. L: low-dose, M: middle-dose, and H: high-dose. ∗P < 0.05, ∗∗P < 0.01 vs. control group, #P < 0.05 and ##P < 0.01 vs. DM group.