FIG 1 .

Schematic of the reverse transcription and integration processes. The HIV-1 RNA genome is copied into a dsDNA molecule by the viral RT (steps 1 to 8). This viral DNA is processed and integrated into the cellular genome by the viral integrase (steps 9 to 11) and cellular DNA repair enzymes (step 12). The different steps are described in more detail in the text. The red star marks mutations in the PPT. the yellow star indicates the base pair extension created at the 5′ end of the strong-stop +DNA (step 6) and at the left end of the viral DNA.