Table 2.

Characterization of dextran sulfate sodium (DSS)-induced colitis in male and female mice.

	Male		Female
	Control (n = 12)	DSS (n = 13)	Control (n = 11)	DSS (n = 10)
Body weight change (% D0)	3.87 ± 0.59	−15.50 ± 1.10***	3.98 ± 1.0	−8.77 ± 1.36***
Disease activity index	0.67 ± 0.28	8.77 ± 0.72**	0.09 ± 0.09	7.71 ± 0.55***
Macroscopic damage score	0.30 ± 0.08	7.35 ± 0.33***	0.48 ± 0.20	5.70 ± 0.54***
Colon length	7.0 ± 0.14	5.4 ± 0.16***	6.70 ± 0.21	5.40 ± 0.23**

D7 observations reveal a decreased percent body weight gain from D0, increased disease activity index and macroscopic damage score after the administration of 2.5% DSS in drinking water from D0–5. **P < 0.01, ***P < 0.001 denotes a significant difference to the respective control.