Skip to main content
. 2018 Apr 4;9:282. doi: 10.3389/fphar.2018.00282

Table 1.

Identification of potential biomarkers of rat plasma samples between control group and cervicitis module group.

No. Name Retention time M.F Error (ppm) Ion mode VIP P-value AUC
1 3-Methyl-5-propyl-2-furanundecanoic acid 18.63 C19H32O3 −1.1 [M+H]+ 1.02 1.19E-06 0.904
2 Acetylcarnitine# 1.11 C9H17NO4 −2.6 [M+H]+ 1.15 1.49E-03 0.786
3 Etiocholanolone# 16.71 C19H30O2 −0.5 [M+NH4]+ 2.87 3.29E-10 0.991
4 LysoPC(18:2) 10.48 C26H50NO7P −3.1 [M+H]+ 10.22 4.41E-04 0.801
5 LysoPC(18:3)# 11.25 C26H48NO7P −4.2 [M+H]+ 2.48 1.71E-09 0.971
6 LysoPC(20:4) 10.55 C28H50NO7P −4.7 [M+H]+ 10.75 8.20E-05 0.813
7 LysoPC(20:5) 10.47 C28H48NO7P −3.6 [M+H]+ 2.14 8.73E-11 0.976
8 LysoPC(22:6) 10.51 C30H50NO7P −4.4 [M+H]+ 4.22 7.30E-03 0.742
9 PC(O-18:1/2:0) 15.77 C28H56NO7P −3.5 [M+H]+ 1.32 8.81E-04 0.809
10 SM(d18:0/16:1) 20.19 C39H79N2O6P −1.2 [M+H]+ 7.74 2.92E-03 0.803
11 Stearoylcarnitine 15.11 C25H49NO4 −1.9 [M+H]+ 1.21 7.00E-10 0.976
12 Tetracosahexaenoic acid 9.96 C24H36O2 −2.6 [M+H]+ 1.95 1.35E-02 0.684
13 Tryptophan 2.7 C11H12N2O2 −1.7 [M+H]+ 1.25 4.48E-02 0.692
14 Pregnenolone 9.44 C21H32O2 −2.8 [M+H]+ 2.34 9.94E-03 0.691
15 Tetradecanoylcarnitine 9.7 C21H41NO4 −3.1 [M+H]+ 1.08 3.40E-02 0.655
16 20-Hydroxyeicosatetraenoic acid 13.18 C20H32O3 −0.4 [M-H]- 1.45 4.55E-02 0.629
17 3b,7a-Dihydroxy-5b-cholanoic acid 9.93 C24H40O4 −0.9 [M-H]– 2.01 1.85E-02 0.675
18 9,10-Epoxyoctadecenoic acid 11.95 C18H32O3 −3.4 [M-H]– 3.86 3.55E-04 0.997
19 Arachidonic acid 8.38 C20H32O2 −1.4 [M-H]– 1.35 4.47E-02 0.622
20 Eicosapentaenoic acid 18.62 C20H30O2 −2.1 [M-H]– 1.70 2.55E-02 0.705
21 Glycocholic acid 6.74 C26H43NO6 −1.8 [M-H]– 1.26 1.24E-02 0.734
22 LysoPE(0:0/20:0) 14.72 C25H52NO7P −1.6 [M-H]– 1.55 1.47E-02 0.718
23 PI(20:4/0:0) 11.12 C29H49O12P −1 [M-H]– 7.49 3.93E-09 0.958
24 S-(PGA2)-glutathione 14.63 C30H47N3O10S 0.3 [M-H]– 1.15 2.10E-04 0.803
25 Taurocholic acid 6.1 C26H45NO7S −1.8 [M-H]– 2.68 2.20E-03 0.845
26 Thymidine 1.83 C10H14N2O5 −0.3 [M-H]– 1.40 1.96E-05 0.904
27 3-Carboxy-4-methyl-5-propyl-2-furanpropionic acid 5.81 C12H16O5 −3.6 [M-H]– 2.24 3.55E-03 0.553

p-value is t-test comparing normal rat and cervicitis rat; confidence intervals of AUC is 95%;

#

means the biomarker was identified in both rat model and human disease.