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. 2018 Apr 4;9:282. doi: 10.3389/fphar.2018.00282

Table 2.

Identification of potential biomarkers of human plasma samples between healthy women and cervicitis patients.

No. Name Retention time M.F Error (ppm) Ion mode VIP P-value AUC
1 1-Acetoxy-2-hydroxy-16-heptadecyn-4-one 11.25 C19H32O4 0.3 [M+H]+ 3.62 5.86E-13 0.993
2 9-Decenoylcarnitine 6.33 C17H31NO4 2.5 [M+H]+ 1.99 1.27E-02 0.805
3 Acetylcarnitine# 0.9 C9H17NO4 0.9 [M+H]+ 1.87 5.63E-04 0.775
4 Cortisol 5.92 C21H30O5 1.5 [M+H]+ 1.11 3.41E-02 0.692
5 Etiocholanolone# 16.9 C19H30O2 1 [M+NH4]+ 2.05 5.55E-08 0.983
6 Linoelaidyl carnitine 10.44 C25H45NO4 2.1 [M+H]+ 2.27 9.78E-04 0.795
7 L-Phenylalanine 1.9 C9H11NO2 −0.2 [M+H]+ 1.01 8.81E-03 0.771
8 L-Valine 0.78 C5H11NO2 0.2 [M+H]+ 1.48 1.96E-06 0.910
9 LysoPC(18:3) 11.34 C26H48NO7P −0.9 [M+H]+ 1.16 3.73E-03 0.801
10 LysoPC(P-18:0) 12.83 C26H54NO6P −0.3 [M+H]+ 1.25 4.04E-02 0.701
11 PC(O-18:1/2:0) 15.99 C28H56NO7P −0.5 [M+H]+ 1.61 6.38E-03 0.780
12 Phytosphingosine 7.46 C18H39NO3 3.5 [M+H]+ 3.36 6.16E-05 0.894
13 Vaccenyl carnitine 11.83 C25H47NO4 0.8 [M+H]+ 2.44 6.37E-04 0.822
14 12,13-Dihydroxy-9-octadecenoic acid 19.24 C18H34O4 1.2 [M-H]– 1.46 1.61E-02 0.675
15 9-Hydroxy-10,12-octadecadienoic acid 12 C18H32O3 2.6 [M-H]– 1.58 7.37E-03 0.735
16 3-Oxoandrostan-17-yl hydrogen sulfate 7.12 C19H30O5S 1.9 [M-H]– 2.28 3.98E-04 0.787
17 gamma-Linolenic acid 18.79 C18H30O2 −1.3 [M-H]– 1.66 2.01E-02 0.777
18 Linoleic acid 20.17 C18H32O2 0.1 [M-H]– 1.27 3.71E-02 0.677
19 LysoPE(18:1/0:0) 11.93 C23H46NO7P 0 [M-H]– 2.08 6.06E-04 0.814
20 LysoPE(18:2/0:0) 10.39 C23H44NO7P 3.4 [M-H]– 1.12 1.25E-02 0.713
21 Palmitoleic acid 19.51 C16H30O2 1.2 [M-H]– 1.60 3.66E-02 0.724
22 PI(20:4/0:0)# 11.31 C29H49O12P −0.7 [M-H]– 3.68 3.32E-07 0.782

p-value is t-test comparing normal women and cervicitis patients; confidence intervals of AUC is 95%;

#

means the biomarker was identified in both rat model and human disease.