Figure 1:

The MICtools pipeline. Each step is implemented as a subcommand of the mictools main command. mictools null estimates the empirical TIC_e null distribution of the M variable pairs (x_i, y_i). mictools pval computes the TIC_e values and estimates their p values (boxes within the dashed line). The multiple testing correction is performed by mictools adjust. Finally, mictools strength estimates the MIC_e value for the subset of significant relationships. The color of the boxes highlights the criterion used for parameter optimization.