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. 2018 Apr 4;9:681. doi: 10.3389/fimmu.2018.00681

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Copyright © 2018 van der Lee, van Rooijen, de Zeeuw-Brouwer, Bogaard, van Gageldonk, Marinovic, Sanders, Berbers and Buisman.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Reverse cumulative distribution curves of IgG levels before and after a tetanus, diphtheria, and acellular pertussis (Tdap) booster vaccination. (A) pertussis toxin (PT), (B) filamentous hemagglutinin, (C) pertactin, (D) diphtheria toxoid, and (E) tetanus toxin specific IgG levels (IU/mL) in Dutch adults 25–29 years of age before (pre; black lines), 2 weeks (red lines), 4 weeks (green lines), 1 year (blue lines), and 2 years (orange lines) after a first Tdap booster vaccination. Note, black line represents the cut-off for protection (PT 20 IU/mL (suggestive), diphtheria and tetanus 0.01 IU/mL).