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. 2018 Apr 4;9:681. doi: 10.3389/fimmu.2018.00681

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Copyright © 2018 van der Lee, van Rooijen, de Zeeuw-Brouwer, Bogaard, van Gageldonk, Marinovic, Sanders, Berbers and Buisman.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cytokine levels of stimulated T-cells before and after a tetanus, diphtheria, and acellular pertussis (Tdap) booster vaccination. (A) Interferon-gamma, (B) interleukin-13, and (C) IL-17 cytokine concentrations (pg/mL) in the supernatants of T-cells stimulated with heat inactivated pertussis toxin (PT) (circles), filamentous hemagglutinin (squares), or pertactin (Prn) (triangles) in Dutch adults 25–29 years of age before 2 weeks and 1 year after a first Tdap booster vaccination. Note, black lines represents the geometric mean concentration; *p-value < 0.05.