Figure 6.

The connection between a bold idea of building the world's first synthetic yeast genome and delivering 16 synthetic chromosomes by the end of this year. A global alliance of a dozen teams from five countries is turning the Yeast 2.0 idea into action. To date, six chromosomes (depicted by green numbers) have been synthesised and swapped out for their native counterparts in Saccharomyces cerevisiae S288c. The full-length synthesis of the 10 remaining chromosomes is almost complete. Most teams are in the process of identifying the causes of fitness defects and debugging these imperfections.