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. Author manuscript; available in PMC: 2018 Apr 11.
Published in final edited form as: JAMA Oncol. 2016 Dec 1;2(12):1539–1540. doi: 10.1001/jamaoncol.2016.2646

Table.

Comparison of X-rays, Protons, and Heavy Ions

Parameter X-rays Protons Carbon Ions
Volume of irradiated normal tissue Large Small Smallest
Biological effectiveness
 In normal tissue Low Low Low
 In tumor tissue Low Low High
Targeting precision Low High Highest
System cost Low High Highest
Worldwide centers, No. Thousands 55 10
Worldwide treated patients, estimate Millions 120 000 15 000