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. Author manuscript; available in PMC: 2018 Apr 11.
Published in final edited form as: Ann Vasc Surg. 2017 Oct 26;46:193–204. doi: 10.1016/j.avsg.2017.10.001

Fig. 3.

Fig. 3

Mechanical tension increases IL-6 and MCP-1 mRNA expression through phosphorylation of STAT3. (A) IL-6 and (B) MCP-1 mRNA expression in aortic tissue held at optimal (1.2 g, n = 7) or elevated tension (1.7 g, n = 7) on an ex vivo tissue myograph. (C) IL-6 and (D) MCP-1 mRNA expression in VSMCs held at static or tension, defined by 12% biaxial cyclic stretch, for 3 hr in complete media with or without 2.5 µM WP1066 (n = 7). *P < 0.05 versus control (static); #P < 0.05 versus tension.