Scheme 6. Synthesis of analogs 48–50 a.
aReagents and conditions: (a) K2CO3, DMSO, 120 °C, 24 h, 25% (b) HATU, iPr2NEt, DMF, 60 °C, 4 h (c) NaBH3CN, AcOH, MeOH, (d) TFA, CH2Cl2, 1 h (e) K2CO3, DMSO, 125 °C, 3 h, 52%.
Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.