Table 8.

Pharmacokinetic Profiles of 61 and 63 in CD1 mice^a

	61		63
Parameter	IV	PO	IV	PO
Cl (L/h/kg)	227	‒	294	‒
T1/2 (h)	0.85	1.94	2.98	3.75
Cmax (μM)	1.45b	1.20	0.74 b	1.78
Tmax (h)	‒	0.25	‒	0.25
AUClast (μM·h)	0.26	3.2	0.19	2.5
Vss (L/kg)	5.6	‒	27	‒
F(%)	‒	49	‒	50

^avalues calculated from drug concentration in plasma following IV (2 mg/kg) and PO (50 mg/kg) dosing. n = 3, 8-time points taken over 24 hours. Compounds 61 and 63 were formulated as solution in PBS buffered saline with 1.1 eq. NaOH (final pH 7–8).

^bC_max = C₀ (t = 0) for IV administration. All pharmacokinetic studies were conducted at Pharmaron Inc.