Fig. 5.

Correlation of urinary miR-196a and risk of ESRD. a Kaplan–Meier curves of renal survival rate stratified by urinary miR-196a tertiles. There were significant differences of the renal survival rate among the different miR-196a tertiles analyzed by the log-rank test. b Association between tertiles of urinary miR-196a with risk of progression to ESRD. HRs with 95% CI was plotted for tertiles of urinary miR-196a. c The additional value of urinary miR-196a in predicting ESRD as assessed by the time-dependent ROC curves. The AUC of model2 (dash line; addition of urinary miR-196a to proteinuria and eGFR, adjusting for age, sex) is superior over time when compared with the AUC of model1 (solid line; including only proteinuria and eGFR, adjusting for age, sex). The overall survival probability is indicated by the dotted line. ESRD end-stage renal disease, HR hazard ratio, 95% CI 95% confidence interval, ROC receiver operating characteristic curve, AUC area under the ROC curve, eGFR estimated glomerular filtration rate