Table 1.

Baseline characteristics for patients with FSGS according to tertiles of urinary miR-196a

Characteristic	Total (n = 231)	Patients according to tertiles of urinary miR-196a			p value
		Tertile 1 (n = 78)	Tertile 2 (n = 77)	Tertile 3 (n = 76)
Age (years)	26.0 (20.0, 41.0)	24.5 (19.0, 39.0)	28.0 (21.0, 42.0)	25.5 (20.0, 42.8)	0.554
Male, % (n)	68.4 (158)	67.9 (53)	66.2 (51)	71.1 (54)	0.810
Hypertension, % (n)	17.3 (40)	10.3 (8)	28.6 (22)	13.2 (10)	0.005
eGFR (mL/min/1.73 m2)	104.07 (62.61, 123.73)	111.57 (82.77, 130.05)	99.75 (57.85, 123.26)	86.23 (55.43, 115.24)	0.005
Proteinuria (g/24 h)	6.93 (3.97, 9.94)	5.49 (2.87, 8.14)	7.80 (4.29, 10.42)	7.15 (5.07, 10.85)	0.003
Albumin (g/L)	21.20 (18.70, 26.90)	22.55 (19.18, 30.03)	20.30 (18.08, 27.20)	20.65 (18.20, 23.98)	0.064
Serum creatinine (mg/dL)	0.91 (0.69, 1.42)	0.82 (0.64, 1.01)	0.95 (0.67, 1.54)	1.03 (0.75, 1.66)	0.005
Total cholesterol (mmol/L)	9.52 (7.48, 12.28)	8.74 (6.86, 11.95)	9.52 (7.67, 12.25)	10.04 (7.94, 13.04)	0.056
Triglyceride (mmol/L)	2.81 (2.02, 3.75)	2.47 (1.77, 3.41)	2.96 (2.25, 4.00)	3.00 (2.17, 4.05)	0.013
Global glomerulosclerosis (%)	0.00 (0.00, 6.06)	0.00 (0.00, 6.67)	0.00 (0.00, 5.44)	0.00 (0.00, 4.89)	0.304
Segmental glomerulosclerosis (%)	12.50 (5.88, 22.22)	9.88 (5.26, 19.78)	12.50 (5.88, 23.30)	14.29 (6.32, 25.00)	0.436
Interstitial fibrosis (%)	4.45 (0.00, 13.39)	2.98 (0.00, 9.86)	4.45 (0.00, 8.95)	7.12 (2.31, 21.21)	0.004
Tubular atrophy (%)	1.01 (0.00, 7.01)	0.76 (0.00, 6.16)	0.82 (0.00, 5.00)	1.70 (0.00, 20.25)	0.038
Patients with nephrotic syndrome, % (n)	80.1 (185)	66.7 (52)	84.4 (65)	89.5 (68)	0.001
Patients progression to ESRD, % (n)	20.3 (47)	7.7 (6)	15.6 (12)	38.2 (29)	< 0.001

Data are shown as median (25th, 75th percentiles) for continuous variables and percent (n) for categorical variables

Conversion factors: serum creatinine in mg/dL to μmol/L, ×88.4

FSGS focal segmental glomerulosclerosis, eGFR estimated glomerular filtration rate