Table 1.
Baseline and demographic characteristics of individuals (n = 4003) older and younger with HIV infection on antiretroviral treatment (ART) from June 2004 to December 2012
| Characteristics | Older (≥ 50 years) N = 262 |
Younger (< 50 years) N = 3741 |
p-value |
|---|---|---|---|
| Year of entry | – | ||
| 2004 | 2 (0.8) | 74 (2.0) | |
| 2005 | 34 (13.0) | 568 (15.2) | |
| 2006 | 39 (14.9) | 574 (15.3) | |
| 2007 | 18 (6.9) | 270 (7.2) | |
| 2008 | 11 (4.2) | 181 (4.8) | |
| 2009 | 34 (13.0) | 369 (9.9) | |
| 2010 | 60 (22.9) | 877 (23.4) | |
| 2011 | 54 (20.6) | 655 (17.5) | |
| 2012 | 10 (3.8) | 173 (4.6) | |
| Age (years), median (IQR) | 54. 5 (52–58) | 32 (28–38) | – |
| Gender, n (%) | |||
| Male | 117 (44.7) | 1321 (35.3) | 0.003 |
| Female | 145 (55.3) | 2420 (64.7) | |
| Clinic site, n (%) | 0.021 | ||
| Urban | 99 (37.8) | 1691 (45.2) | |
| Rural | 163 (62.2) | 2050 (54.8) | |
| Median body mass index (kg/m2), (IQR)a | 23.1 (20.5–27.1) | 22.8 (20.2–26.4) | 0.154 |
| Baseline CD4+ count, (cells/μl) median(IQR)b | 142 (86–197) | 124 (60–184) | < 0.001 |
| CD4+ cell count, cells/mm3: n (%) | 0.119 | ||
| < 200 | 173 (76.5) | 2747 (81.2) | |
| 200–350 | 45 (19.9) | 568 (16.8) | |
| > 350 | 8 (3.5) | 70 (2.1) | |
| Viral load (log copies/ml), mean (SD)e | 4.9 (1.0) | 5.0 (0.9) | 0.268 |
| WHO stage, n (%)c | 0.623 | ||
| 1 | 40 (15.3) | 556 (14.9) | |
| 2 | 60 (22.9) | 744 (20.0) | |
| 3 | 131 (50.0) | 2004 (53.8) | |
| 4 | 31 (11.8) | 424 (11.4) | |
| Past history of TB, n (%)d | 62 (24.2) | 1077 (29.5) | 0.075 |
| Prevalent TB, n (%) | 62 (23.7) | 907 (24.2) | 0.882 |
| Co-morbidities | |||
| Hypertensione | 55 (21.5) | 79 (2.2) | <.001 |
| Diabetesf | 16 (6.3) | 24 (0.7) | <.001 |
| Occupationg | 0.014 | ||
| Employed | 83 (32.2) | 1193 (32.3) | |
| Unemployed | 156 (60.5) | 2358 (63.9) | |
| Scholar/Other | 19 (7.4) | 137 (3.7) | |
| Initial ART regimen | |||
| 2NRTI + NNRTI | 260 (100%) | 3718 (99.6%) | |
| 2NRTI + PI | 0 | 15 (0.4%) | |
a221 missing BMI (8 older, 213 younger), b392 missing CD4 count(36 older, 356 younger), c13 younger missing WHO stage, d102 missing past history of TB (6 older,96 younger), e475 missing viral load (34 older,441 younger), e96 missing hypertension (6 older,90 younger), f96 missing diabetes (6 older,90 younger), g57 missing occupation(4 older, 53 older)