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. 2018 Apr 10;11:21. doi: 10.1186/s13041-018-0365-8

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — (a) Continuous injection of morphine for 7 days induced the formation of morphine analgesic tolerance. The data are expressed as the mean ± s.e.m. (n = 8 in each group). **P < 0.01, ***P < 0.001, Two-way repeated-measures of ANOVA followed by Bonferroni test. Ten samples (n = 5 in each group) were subjected to microarray analysis. b-c The entire and partial hierarchical clusterings of the lncRNAs and mRNAs, respectively; the up- and down-regulated genes are colored in red and green, respectively. d Scatter plot displaying the lncRNAs and mRNAs that exhibited expression differences between the MT and NS groups that exceeded 1.5-fold