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. 2018 Apr 10;18:63. doi: 10.1186/s12903-018-0524-4

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Box diagrams showing concentrations of ferritin, hepcidin, and hepcidin/ferritin (ng/mL, median [IQR]) in serum and saliva among the control, CP, T2DM, and T2DM with CP groups. Blue boxes represent control group participants, yellow boxes represent CP participants, purple boxes represent T2DM participants, and red boxes represent CP with T2DM participants. Median and interquartile range was presented by boxes, and maximum and minimum values were indicated using bars of each group. One indicator of both serum and saliva was put into one image. Shaded boxes represent indicators of saliva detection, whereas no shadows represent those of serum detection. Serum ferritin and hepcidin levels were significantly higher in the CP and CP with T2DM groups than in the control group (a, b, P* < 0.05). In addition, serum ferritin and hepcidin concentrations were significantly higher in the CP group than in the T2DM group (a, b, P* < 0.05). The change trend of serum hepcidin was similar to that of serum ferritin. The serum hepcidin/ferritin value was significantly lower in the CP with T2DM group than in the T2DM and control groups (c, P* < 0.05). Detection of saliva samples revealed higher ferritin levels in the CP and T2DM groups (a, P < 0.05). The salivary hepcidin levels were relatively low (b). Significant differences are indicated by asterisk (*, P < 0.05)