Table 2.
Univariate and multivariate regression analysis of factors associated with mortality in EMPD patients
| Variables | HR (95% CI) | p value | aHR (95% CI) | p value |
|---|---|---|---|---|
| Anatomic sites | ||||
| Vulva or labial | reference | reference | ||
| Skin | 1.48 (1.27, 1.73) | <0.001 | 0.95 (0.75, 1.20) | 0.677 |
| Penis or scrotum | 1.14 (0.95, 1.38) | 0.171 | 0.83 (0.60, 1.15) | 0.260 |
| Vagina | 2.64 (0.73, 9.60) | 0.969 | 3.26 (2.03, 5.23) | <0.001 |
| Others | 1.99 (1.53, 2.62) | <0.001 | 1.36 (0.97, 1.90) | 0.071 |
| Concurrent malignancy | ||||
| No | reference | reference | ||
| Yes | 1.59 (1.37, 1.83) | <0.001 | 1.15 (0.99, 1.34) | 0.058 |
| Tumor size | ||||
| Less than 2 cm | reference | reference | ||
| More than 2 cm | 1.01 (0.83, 1.24) | 0.887 | 0.92 (0.76, 1.11) | 0.377 |
| Distant metastasis | ||||
| No | reference | reference | ||
| Yes | 3.49 (2.27, 5.35) | <0.001 | 3.36 (2.27, 4.98) | <0.001 |
| Surgery | ||||
| No | reference | reference | ||
| Yes | 0.49 (0.39, 0.61) | <0.001 | 0.77 (0.61, 0.97) | 0.030 |
| Radiation | ||||
| No | reference | reference | ||
| Yes | 2.37 (1.83, 3.06) | <0.001 | 1.60 (1.18, 2.15) | 0.002 |
| Age | 1.09 (1.08, 1.10) | <0.001 | 1.09 (1.08, 1.10) | <0.001 |
| Gender | ||||
| Female | reference | reference | ||
| Male | 1.35 (1.17, 1.55) | <0.001 | 1.42 (1.10, 1.85) | 0.008 |
| Race | ||||
| White | reference | reference | ||
| Black | 0.72 (0.38, 1.34) | 0.295 | 0.65 (0.28, 1.51) | 0.313 |
| Others | 0.79 (0.66, 0.94) | 0.010 | 0.81 (0.67, 0.97) | 0.026 |
| High latitude state | ||||
| No | reference | reference | ||
| Yes | 1.06 (0.92, 1.21) | 0.427 | 0.98 (0.85, 1.13) | 0.803 |
Unknown data for tumor size and race are not shown on the table.
Boldface with italics indicates significant effect. p-value < 0.05