Table 3.
Univariate and multivariate regression analysis of factors associated with mortality in EMPD patients by radiation treatment
| Without radiation treatment | With radiation treatment | |||||||
|---|---|---|---|---|---|---|---|---|
| Variables | HR (95% CI) | p value | aHR (95% CI) | p value | HR (95% CI) | p value | aHR (95% CI) | p value |
| Anatomic sites | ||||||||
| Vulva or labial | reference | reference | reference | reference | ||||
| Skin | 1.48 (1.26, 1.75) | <0.001 | 0.97 (0.77, 1.24) | 0.833 | 0.80 (0.47, 1.34) | 0.391 | 0.62 (0.24, 1.65) | 0.342 |
| Penis or scrotum | 1.10 (0.90, 1.34) | 0.337 | 0.78 (0.56, 1.08) | 0.134 | 0.95 (0.49, 1.84) | 0.888 | 0.81 (0.26, 2.47) | 0.709 |
| Vagina | 1.90 (0.47, 7.71) | 0.369 | 3.20 (1.71, 5.97) | <0.001 | 7.26 (3.89, 13.53) | <0.001 | 5.76 (2.34, 14.19) | <0.001 |
| Others | 1.96 (1.46, 2.64) | <0.001 | 1.61 (1.15, 2.25) | 0.005 | 1.03 (0.52, 2.04) | 0.925 | 0.68 (0.27, 1.73) | 0.421 |
| Concurrent malignancy | ||||||||
| No | reference | reference | reference | reference | ||||
| Yes | 1.56 (1.34, 1.82) | <0.001 | 1.14 (0.97, 1.33) | 0.107 | 1.57 (1.01, 2.44) | 0.043 | 1.21 (0.70, 2.07) | 0.498 |
| Tumor size | ||||||||
| Less than 2 cm | reference | reference | reference | reference | ||||
| More than 2 cm | 1.01 (0.82, 1.24) | 0.916 | 0.91 (0.75, 1.11) | 0.337 | 1.61 (0.86, 3.01) | 0.133 | 1.17 (0.54, 2.53) | 0.691 |
| Distant metastasis | ||||||||
| No | reference | reference | reference | reference | ||||
| Yes | 3.11 (1.88, 5.14) | <0.001 | 3.43 (2.13, 5.52) | <0.001 | 2.80 (1.59, 4.92) | <0.001 | 2.71 (1.21, 6.10) | 0.016 |
| Surgery | ||||||||
| No | reference | reference | reference | reference | ||||
| Yes | 0.50 (0.39, 0.65) | <0.001 | 0.70 (0.55, 0.89) | 0.004 | 0.83 (0.51, 1.35) | 0.455 | 0.88 (0.48, 1.63) | 0.688 |
| Age | 1.09 (1.08, 1.10) | <0.001 | 1.09 (1.08, 1.10) | <0.001 | 1.06 (1.03, 1.09) | <0.001 | 1.06 (1.03, 1.09) | <0.001 |
| Gender | ||||||||
| Female | reference | reference | reference | reference | ||||
| Male | 1.35 (1.17, 1.56) | <0.001 | 1.50 (1.15,1.95) | 0.003 | 0.81 (0.53, 1.24) | 0.328 | 1.14 (0.47, 2.76) | 0.771 |
| Race | ||||||||
| White | reference | reference | reference | reference | ||||
| Black | 0.69 (0.32, 1.48) | 0.338 | 1.15 (0.45, 2.91) | 0.770 | 0.49 (0.20, 1.22) | 0.125 | 0.43 (0.15, 1.20) | 0.108 |
| Others | 0.82 (0.68, 0.98) | 0.032 | 0.86 (0.71, 1.05) | 0.132 | 0.54 (0.26, 1.14) | 0.107 | 0.44 (0.22, 0.91) | 0.026 |
| High latitude state | ||||||||
| No | reference | reference | reference | reference | ||||
| Yes | 1.09 (0.94, 1.26) | 0.251 | 1.06 (0.91, 1.22) | 0.456 | 0.70 (0.44, 1.12) | 0.140 | 0.52 (0.30, 0.90) | 0.019 |
Unknown data for tumor size and race are not shown on the table.
Boldface with italics indicates significant effect. p-value < 0.05