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. 2018 Apr 10;18:63. doi: 10.1186/s12872-018-0805-5

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Action potential recordings in atrial myocytes from control, GK and metformin-treated GK rats. a Representative action potential parameters (APA, RP, APD₅₀ and APD₉₀) in freshly isolated atrial myocytes before exposure to apamin. b Action potential before and after exposure to apamin (100 pM for 15 min). c Changes in APD₅₀ and APD₉₀ after exposure to apamin. Non-normal distributed data were represented as median with interquartile range (n = 11-12 cells from three rats in each group); * represents P < 0.05 vs Con; ** represents P < 0.01 vs Con; ^{# #} represents P < 0.01 vs GK