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. 2018 Apr 10;18:56. doi: 10.1186/s12935-018-0554-7

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — The methylation levels of RUNX3 and TGF-β in metastatic vs. primary renal cancer xenograft model. a CpG methylation levels of RUNX3 and TGF-β in metastatic xenograft model was detected by using qMSP compared with primary renal xenograft cancer model (**p < 0.01). The data were mean ± SD of three independent experiments. b Global DNA methylation levels of RUNX3 and TGF-β in metastatic xenograft model were detected by using quantitative methylation real-time PCR compared with primary renal xenograft cancer model (**p < 0.01). The data were mean ± SD of three independent experiments