The effects of exogenous recombinant human Netrin-1 (rh-NTN-1) on neurological function and brain edema after SAH. Administration of exogenous rh-NTN-1 at a dose of 45 µg/kg markedly improved neurological impairments (A, B) and reduced brain water content in the left and right hemispheres (C, D) both at 24 h and 72 h post-SAH. n=6/group. *P<0.05 vs sham; #P<0.05 vs PBS, rh-NTN-1 (5 µg/kg), and rh-NTN-1 (15 µg/kg). BS, brain stem; Cb, cerebellum; LH, left hemisphere; and RH, right hemisphere.