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. Author manuscript; available in PMC: 2019 Mar 1.
Published in final edited form as: Brain Behav Immun. 2017 Nov 21;69:190–202. doi: 10.1016/j.bbi.2017.11.012

Fig. 8.

Fig. 8

The effects of UNC5B siRNA on the neuroprotection associated with recombinant human Netrin-1 (rh-NTN-1) at 24 h after SAH. Knockdown of UNC5B significantly abolished the neuroprotective effects of rh-NTN-1 against neurological impairments (A) and brain edema (B) at 24 h post-SAH. (C) UNC5B siRNA efficiently knocked down UNC5B expression in the ipsilateral cortex. n=3/group. *P<0.05 vs Scr siRNA. Knockdown of UNC5B abolished the effects of rh-NTN- 1 on the promotion of PPARγ expression, and inhibition of the expression of NFκB, TNF-α, IL-6, and ICAM-1, as well as MPO in the ipsilateral cortex (D–J). Relative densities of each protein have been normalized against the sham group. n=6/group. *P<0.05 vs sham; #P<0.05 vs PBS; and &P<0.05 vs rh-NTN-1 and rh-NTN-1+Scr siRNA. UNC5B siRNA, UNC5B siRNA; Scr siRNA, scrambled siRNA.