Table 2.
Summary of gene signatures that classify interstitial lung diseases.
| # Genes | Tissue origin | Disease comparison | Sample size | Year | Reference |
|---|---|---|---|---|---|
| 407 | Lung | Idiopathic pulmonary fibrosis (IPF) vs HP | 15 (IPF)12 (HP) | 2006 | (5) |
| 332/6 | Lung | Sporadic IPF vs familial, IPF vs non-specific interstitial pneumonitis (NSIP) | 16 sporadic IPF (2 NSIP)10 familial (4 NSIP) | 2007 | (8) |
| 242/335 | Lung, fibroblasts | CTRL vs (SScPF; SScPAH; iPAH; IPF) | 33 (15 severe PF, 6 moderate/severe PF and PAH, 4 moderate PF with PAH, 7 PAH), 10 IPF | 2011 | (75) |
| <50 | Lung | SSc/IFP; IPF vs NSIP | ≤10 | 2007, 2011 | (8, 75) |
| 22 | Lung | IUP vs (non-IUP, sarc, HP) | 77 training set (39 IUP, 38 non-IUP), validation set 48 (22 IUP, 26 non-IUP) | 2015 | (19) |
| 4,734 | Lung | PH-IPF and PAH vs CTRL | 18 (PAH), 8 (PH-IPF) | 2010 | (76) |
| 74 | Lung | Chronic lung disease | 13 data sets | 2015 | (77) |
| >1,500/32a | LCM lung | PH-IPF vs CTRL, PH-chronic obstructive pulmonary disease (COPD) vs CTRL, PH-IPF vs PH-COPD | LCM pulmonary arterioles (n = 8) | 2014 | (78) |
| 255 | LCM lung | PH-IPF vs NPH-IPF | 8 PH-IPF, 8 NPH-IPF | 2013 | (79) |
| 2,490b337c214d | Lung | IPF vs COPD vs CTRL | 19 IPF, 49 COPD | 2016 | (18) |
| 3 Gene clusters | Lung | IPF vs COPD vs CTRL | 319 (3 data sets)e | 2015 | (15) |
a32 small DEGs overlap between PH-IPF and PH-COPD.
b2,490 DEGs between IPF and CTRL.
cDEGs between COPD and CTRL.
dDEGs overlap between IPF and COPD.
e4,259 mRNA and 438 microRNA and also includes 669 clinical variables.