Table 3.
Gene Modules Identified as Significantly Associated with Nontuberculous Mycobacterial Disease by Weighted Gene Coexpression Gene Network Analysis
| Module Name | No. of Genes | Correlation with pNTM Disease | P Value | Relevant Enriched GO Terms |
|---|---|---|---|---|
| Cyan | 1,139 | −0.31 | 0.02 | Thymic T cell selection |
| T cell receptor signaling pathway | ||||
| Antigen processing and presentation | ||||
| Greenyellow | 85 | −0.32 | 0.02 | Cellular defense response |
| Positive regulation of immune response | ||||
| T cell activation | ||||
| T cell receptor complex | ||||
| Natural killer cell mediated cytotoxicity | ||||
| CCR1 chemokine receptor binding | ||||
| Lightcyan | 37 | −0.27 | 0.05 | B cell activation |
| B cell receptor complex | ||||
| MHC class II protein complex |
Definition of abbreviations: GO = gene ontology; MHC = major histocompatibility complex; pNTM = pulmonary nontuberculous mycobacterial.