Table 3.
Gene Modules Identified as Significantly Associated with Nontuberculous Mycobacterial Disease by Weighted Gene Coexpression Gene Network Analysis
Module Name | No. of Genes | Correlation with pNTM Disease | P Value | Relevant Enriched GO Terms |
---|---|---|---|---|
Cyan | 1,139 | −0.31 | 0.02 | Thymic T cell selection |
T cell receptor signaling pathway | ||||
Antigen processing and presentation | ||||
Greenyellow | 85 | −0.32 | 0.02 | Cellular defense response |
Positive regulation of immune response | ||||
T cell activation | ||||
T cell receptor complex | ||||
Natural killer cell mediated cytotoxicity | ||||
CCR1 chemokine receptor binding | ||||
Lightcyan | 37 | −0.27 | 0.05 | B cell activation |
B cell receptor complex | ||||
MHC class II protein complex |
Definition of abbreviations: GO = gene ontology; MHC = major histocompatibility complex; pNTM = pulmonary nontuberculous mycobacterial.